Objective : Base on clinical practice, the authors report a case of tardive dyskinesia
arising during the course of treatment with resperidal.
Methods : This article was review and analysis of a case on risperidone-induced
tardive dyskinea.
Results : Mrs K, a 51-year-old women with a 1-year history of schizophrenic
disorder, gradually developed tardive dyskinetic movement of the mouth, lip, and tongue
over a 4 month period(From July 1996 to June 1997) while taking risperidone. Initially
she was treated with haloperidol and alprazolam. However, the haloperidol was
subsequently discontinued because of EPS developed.
From 11th March 1997, she was observed to have a severe form of tardive dyskinesia
involving her tongue, lip, and mouth. After risperidone was withdrawn at 9th May 1997,
her tardive dyskinetic movement was disappeared.
Conclusions : This is, to our knowledge, the first report of the onset of tardive
dyskinesia in a patient taking risperidone. However, additional controlled studies of
specific questions are needed ; e.g., the dose-response curves for produce tardive
dyskinesia and the mechanism of producing risperidone-induced tardive dyskinea and so
on.
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